Focus

Digital plant phenotyping platform.

2018
The Institute of Biosciences and Bioresources of the National Research Council (IBBR-CNR) hosted a training course at ALSIA - Centro Ricerche Metapontum Agrobios, on a high-throughput and digital plant phenotyping platform. The course aimed at introducing the emerging field of mechanized plant phenotyping. The platform uses imaging methodologies to collect data for complex studies related to plant growth, yield and adaptation to biotic or abiotic stresses. The course has been attended by almost ...

Visible Light Communication: back to the origin or leap of faith?

2018
Best things in life are free! Visible Light Communication (VLC) allows high rate data transmission while illuminating. Are we going back to more than 100 years ago when Bell performed his transmissions through a photophone? By sure, we are using the same principles. It is sufficient to quickly switch on and off the LED light to transmit a wide bandwidth signal invisible to the human eye and completely safe for the human body. VLC can be applied in several fields: - In office or at home, ...

Verso nuovi modelli neuronali per la cura della malattia di Huntington

2018
' in uscita ad aprile, sulla rivista scientifica 'Stem Cell Research', uno studio che apre nuove prospettive per la cura della malattia di Huntington, frutto della collaborazione tra Andrea Ilari dell'Istituto di biologia e patologia molecolari (Ibpm) del Cnr di Roma e Ferdinando Squitieri dell'Irccs 'Casa Sollievo della sofferenza' di San Giovanni Rotondo (Foggia). Il lavoro nasce dall'esigenza di scoprire i meccanismi molecolari coinvolti nello sviluppo di questa patologia genetica ...

Large scale simulation of wireless technologies for connected vehicles

2018
The recent events related to pedestrians killed by self-driving cars have driven the attention to the risks and potentialities of the new automotive technologies and to the relative ethic and legal issues. However, it is by now clear that an autonomous vehicle is safer and more efficient than a human-driven car, since it has no reaction time and it can instantaneously brake, thus also increasing the road capacity and the traffic efficiency. But actual on-board sensors, even if advanced, ...

Scoperta nella regolazione di fattori cruciali per la formazione dei tumori

2018
Nuovo studio sulla rivista Oncogene finanziato da Airc. Regina Elena e Ibpm-Cnr: scoperta regolazione di fattori cruciali per la formazione dei tumori. «La proteina Aurora B - spiega Cinzia Rinaldo (leader del gruppo IBPM) - è spesso deregolata nei tumori e il suo malfunzionamento può portare alla formazione e progressione dei tumori». Dice Gennaro Ciliberto, direttore dell'Ospedale Regina Elena pe rlo Studio e la Cura dei Tumori di Roma: «Il lavoro aggiunge un nuovo tassello che chiarisce ...

Distrofia di Duchenne, un gene artificiale apre la strada a nuove terapie

2018
Progettati nuovi geni artificiali 'immuno-mimetici' in grado di favorire il recupero muscolare. I risultati dello studio, condotto dal Cnr (IBPM e IBCN), sono stati pubblicati su BBA Molecular Basis of Disease (Marzo 2018). Si chiama Jazz-Zif1 (JZif1) il nuovo gene artificiale capace di aumentare i livelli di utrofina, una proteina in grado di supplire parzialmente all'assenza o al mal funzionamento della distrofina, causa di una delle malattie genetiche più difficili da trattare, la Distrofia ...

UNDERSTANDING THE BASIS OF CANCER RESISTANCE TO THERAPEUTIC DRUGS

2017
Resistance to cancer chemotherapeutics, e.g. taxanes and anthracyclines, is largely due to the overexpression of efflux pumps, in particular ABCB1 (P-glycoprotein or MDR1). Resistance leads to poor clinical outcome. Overexpression of a group of genes that surround the ABCB1 genomic locus (the ABCB1 amplicon), including Sorcin (SRI), may contribute to the establishment of the multidrug-resistant phenotype. Here we show that: i) Sorcin is overexpressed in several tumors and cancer cell lines, in ...

Neuroscienze: trovato il legame tra personalità e forma del cervello

2017
Come le differenze individuali nella struttura e funzione cerebrale siano legate al modo in cui ci comportiamo e proviamo emozioni e' una di quelle domande "esistenziali" alla quale gli scienziati cercano di dare una risposta da anni. Benchè risultati conclusivi non siano ancora disponibili, i dati raccolti fino ad ora hanno mostrato un forte legame tra la "forma" di alcune aree cerebrali e le varie caratteristiche di personalità. E' la conclusione di un recente studio effettuato da un team ...

PLANT BIOLOGY: THE MOLECULAR BASES OF PLANT DEVELOPMENT AND REPRODUCTION

2017
The correct synchronization of development of the different tissues of the male organ (stamen) in flowers is essential for male fertility in self-pollinating plants. In this work we demonstrate that the correct distribution of auxin, a plant morphogen, is essential to ensure this synchronization in the model plant Arabidopsis, and that the middle layer - a stamen tissue of previously unknown function - is crucial in generating a developmentally instructive auxin distribution. These findings ...

SWIM (SWitchMiner)

2017
Over the last two decades, biological sciences have undergone radical transformation through the development of new research technologies that have produced a real explosion in the amount of data available. Just think of the modern genomic sequencing techniques that have made the sequencing of the human genome, different animal and plant organisms, and many microorganisms simpler, less expensive and more reliable with enormous benefits for diagnosis and treatment of diseases. In the wake of the ...

MODEL ORGANISMS TO DISSECT THE MECHANISMS OF CELL DIVISION

2017
INT6/eIF3e is a highly conserved protein involved in several processes and downregulated in many human cancers. In this work, we show that loss of Int6 alters spindle microtubule behavior in mitosis, and hence affects the accuracy of chromosome segregation, by regulating the stability of specific mitotic proteins. Article: The Drosophila orthologue of the INT6 oncoprotein regulates mitotic microtubule growth and kinetochore structure Renda F, Pellacani C, Strunov A, Bucciarelli E, Naim V, ...

Nanomateriali avanzati con trasmissione caratteristica straordinaria

2017
Nell'ambito di uno studio realizzato in collaborazione tra due diversi istituti del CNR, ricercatori hanno sviluppato nuovi nanomateriali in oro con straordinarie capacità di trasmissione. La ricerca è stata pubblicata in ACS Nano (Impact Factor 13.942), una delle riviste più importanti e prestigiose al mondo nel settore delle nanotecnologie. La ricerca è stata condotta dal team CNR-Nanotec coordinato da Antonio De Luca in collaborazione con il team dell'ISASI-CNR coordinato da Lucia Petti ...

CLINEXTRACT: A structured lexicon for the automated extraction of clinical concepts from the multisource medical records of aged people with hearing disabilities

2017
Hearing impairment is very common in older adults: 360 million people over 65 have disabling hearing loss worldwide. It is well recognized that a successful plan for hearing rehabilitation of older people shall take into account not only the technological aspects, such as what type of hearing aid or implanted hearing device is used, but also other aspects broadly related to auditory disability. In this view, key factors include the perceived hearing difficulties in real life, the impact on ...

ELIXIR EXCELERATE, AN EUROPEAN PROJECT FOR BIOINFORMATICS TRAINING IN THE LIFE SCIENCES

2017
The European consortium Elixir is devoted to coordinate, integrate and sustain bioinformatics resource in LIfe Science research accross Eurpean countries. In this article, the IBPM coordinator and coordinators of other European nodes operating in the ELIXIR-EXCELERATE project (https://www.elixir-europe.org/about-us/how-funded/eu-projects/excelerate), describe the Train-the-Trainer (TtT) programme, designed to empower scientists to deliver high-quality training in bioinformatics. The TtT ...

AN INNOVATIVE STRATEGY TO KILL CANCER CELLS

2017
Cancer cells show profoundly altered mitotic divisions, and mitotic proteins are viewed as potential targets of novel antineoplastic drugs. Here, we have developed an in silico virtual screening to identify one small molecule targeting the interaction surface between microtubules and the kinetochore protein Hec1, thereby blocking microtubule dynamics. This small molecule effectively inhibits neoplastic growth, both in cultured cancer cells and in murine xenograft models, by promoting mitotic ...

The importance of worker reputation in crowd-work systems

2017
Crowd work is a term often adopted to identify networked systems that can be used for the solution of a wide range of complex problems by integrating a large number of human and/or computer efforts. Among several different types of crowd work systems that are already operational in the Internet, a large research effort has been devoted to characterize the performance of microtask-based crowd work systems. The key characteristic of these systems is that a requester structures his problem in a set ...

A calendar to raiise funds for AIRC

2017
I volti delle donne" is a photo project ideated by Manuela Lanzafame, postdoc at the Institue of Molecular Genetics IGM-CNR of Pavia. Portraits of fourteen girls were used to describe different expression characterizing women and were used to realize a calendar. Earnings will be entirely devolved to the Italian foundation for cancer research (AIRC).

Opinion dynamics in a social network

2017
Dating back to the 60's, and particularly since the advent and successful proliferation of social media, a significant effort has been devoted by the research community to the development of mathematical models describing the evolution of opinions/beliefs in an ecosystem composed of socially interacting individuals. The goal is to gain insights into collective dominant social behaviors and into the impact of different components of the system while being able to predict possible outcomes of ...

Un gustoso 'fiore nero'

2017
Versatile in cucina e benefico per le sue proprietà antiossidanti e depurative, il carciofo è presente sulle nostre tavole, grazie alle tante varietà presenti in tutta Italia, coltivabili da ottobre a giugno. Al nostro Paese, tra l'altro, spetta il primato della produzione mondiale, pari a 500 mila tonnellate, di cui il 35% in Puglia, il 32% in Sicilia, il 21% in Sardegna, il 7% in Campania e il 4% nel Lazio, su una superficie totale di circa 47.000 ettari. Ben 4 varietà con marchio ...

Two genomic regions and lifestyle factors associated with human longevity.

2017
Genomic analysis of longevity offers the potential to illuminate the biology of human aging. In a study, recently published in Nature Communications, a genome-wide association meta-analysis of 606,059 parents' survival, helped discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). Previous suggestions that APOE, CHRNA3/5, CDKN2A/B, SH2B3 and FOXO3A influence longevity have also been validated. Next, the study shows that giving up smoking, educational attainment, openness to new ...

Spatiotemporal classification of mobile network demands

2017
The surge in mobile data traffic -estimated globally at 3.7 exabytes in 2015, with a 74% increase over 2014 and an overall 4,000-fold growth over the past ten years- has fostered the interest of the computer network community towards better understanding the dynamics of the mobile demand. Indeed, a proper characterization of how mobile services are consumed by subscribers can enable an informed, more efficient tailoring of network resource planning and management to the end users' needs. ...

Non-coding RNA: the DNA damage fingerprints of cancer cells

2017
The integrity of our genome has to be maintained ed to prevent accumulation of harmful mutations, or cell death. This is even more needed in tumor cells where breaks in DNA occur at higher frequency. This feature of cancer cells can be exploited to set up therapeutic strategies based on inhibition of DNA repair with the aim to induce cell death. The drugs used so far to strike this "Achilles heel" of cancer cells block the enzymatic activity of essential DNA repair proteins, such as ATM, ATR or ...

FORESTE, CAMBIAMENTI CLIMATICI E ADATTAMENTO

2017
Fornire al settore forestale europeo migliori conoscenze, metodi e strumenti per ottimizzare la gestione e l'uso sostenibile delle risorse genetiche forestali, è un obiettivo sempre più rilevante soprattutto in un contesto di cambiamenti climatici a cui il nostro pianeta sta andando incontro. Per raggiungere questo obiettivo, una delle nostre ricerche (www.gentree-h2020.eu) si sta concentrando principalmente sullo studio delle basi molecolari dell'adattamento di 12 specie arboree forestali, ...

Biochemical adaptations and biotechnological applications of marine cold-adapted organisms

2017
Antartide è un ancora un'area inesplorata per molti aspetti, incluso la diversità biologica e, anche più, diversità chimica. Grazie alla sua storia evolutiva ed isolamento ecologico, ambienti marini ed Antartici si sono aspettati di ospitare comunità biologiche ed uniche che potevano bioactive di romanzo di biosynthesize combina, potenzialmente prezioso per molte domande come pharmaceuticals, supplementi nutritivi e cosmeceuticals. I nostri scopi sono: 1) assaggiare nuovo / noto, ...

Migrations and integrations in Italy

2017
Most of the Institute's researchers and associates, also benefiting from the collaboration of colleagues from other organizations that have been working with us for a long time, contributed to the book. It gathers a total of 27 essays on various aspects of the changing aspects of internal and international mobility, one of the social phenomena of utmost importance and on which the Institute has developed ample expertise that enables it to study this phenomenon from various points of view and ...

Landslides in the Solar System

2017
On Earth, landslides are hazardous phenomena often associated with economic damage and loss of human lives. The most common natural triggers of terrestrial landslides are intense or prolonged rainfall, earthquakes, rapid snow melting, and volcanic activity. But what are the main natural triggers of landslides on other solid bodies of the Solar System? Since the early 70's of the last century, landslides were observed on the surface of the Moon, Mars, Mercury and Venus, to mention only the ...

Muscle Cell News

2017
The e-scientific newsletter Connexon Creative highlights as THIS WEEK'S TOP STORY the paper "Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity", result of a research carried out in our Institute (https://www.musclecellnews.com/issue/). Connexon Creative sifts through all of the most recent scientific literature and news, and selects the most relevant and highest impact publications on regenerative medicine. This week, it ...

Anticorpo monoclonale contro la leucemia mieloide acuta

2017
Su iniziativa del gruppo Menarini e di Oxford BioTherapeutics è stato sviluppato un anticorpo monoclonale, umanizzato, MEN1112 che è in grado di riconoscere ed eliminare cellule di leucemia mieloide acuta. Dopo una fase preclinica di studio e caratterizzazione, che ha dimostrato efficacia e tollerabilità, MEN1112 è stato ed è utilizzato in uno uno studio di tipo traslazionale nel quale l'anticorpo ha dimostrato promettente attività in campioni di sangue periferico e midollare di pazienti ...

Highlights 2017

2017
Highlights 2017 (see for details www.SPIN.CNR.it) Superconductivity Physical Review - R. Cristiano Physical Review - Z. J. Ying, M. Cuoco Physical Review Letters - A. Martinelli, P. Manfrinetti, A. Provino, F. Caglieris, G. Lamura, M. Putti Scientific Reports - C. Nappi, C. Camerlingo, E. Bellingeri, V. Braccini, C. Ferdeghini, E. Sarnelli Supercond. Sci. Technol. - I. Pallecchi, A. Leveratto, V. Braccini, V. Zunino, A. Malagoli Physical Review Materials - G. ...

Scientific report 2016-17

2017
Report of the Scientific activities for thee period 2016-17