The Department of Biomedical Sciences manages the research activity in Biology, Medicine and Public Health. It provides technologies and services to both the public and the private area, with the purpose of promoting knowledge on the fundamental mechanism governing physiological and pathological aspects in living organism, starting from basic research in life sciences to the study of human diseases and of innovative therapeutic interventions. The ultimate aim is to explore new opportunities for ameliorating the health of mankind.
The fundamental activities regard oncology, neurodegenerative diseases, cardiovascular and pulmonary diseases, immunology and infectious diseases, epidemiology and health care research, Biology and biomedical technologies. In these areas, some technologies have been developed and they have found a wider use in the different benchmark areas: proteomics, pharmacogenomics, advanced calculus in bioinformatics and system biology, robotic systems for the limbs’ rehabilitation, molecular diagnostics and imaging.
Just like mechanical properties and chemical compositions of materials are of fundamental importance in buildings, the cells that build up every living organism have different properties and shapes depending on their function and state. Uncontrolled modifications in the cells elasticity, or in the elasticity of any biological tissues in general, are symptoms and effects of pathologies
It emerges from a study on plant remedies used in Italian folk medicine between the nineteenth and twentieth centuries conducted by researchers at the Institute for Agricultural and Forest Systems in the Mediterranean in collaboration with the Institute of Neurological Sciences of the National Research Council (Cnr). In this work, about 42% of the plant-based treatments utilized by Italian folk medicine to heal headache seems to represent the continuity of the medical tradition over about two thousand years. The results were published in the Journal of Ethnopharmacology
A new study, lead by the group of Daniele Catalucci from the Cnr-Irgb (Milan, Italy) and part of the EU-funded project CUPIDO, demonstrated that nanoparticle-based therapeutic peptides can effectively be delivered to the diseased heart via inhalation. Their results, published in the journal Science Translational Medicine, represent the first proof-of-concept for an unconventional and pioneering approach with inhalable nanoparticles to pharmacologically treat cardiac conditions
The human brain uses the signals that come from the senses to adjust its behavior: for example, we hurry to turn off the stove if we feel the smell of burned from the roast that we are baking. In people suffering from neurological or psychiatric illnesses such as stroke, multiple sclerosis, schizophrenia, these mechanisms are compromised and the processing of incoming sensory signals is altered due to communication distortions in neuronal networks
A team led by Elvira De Leonibus (Neuropsychormacology lab at the Institute of Genetics and Biophysics of the Italian National research council, Igb-Cnr), in Naples and Telethon Institute of Genetic and Medicine in Pozzuoli) in collaboration with Barbara Picconi from Fondazione Santa Lucia and Paolo Calabresi from the University of Perugia has identified a new mechanism of cellular memory induced by motor learning, which is impaired in the early phases of Parkinson’ disease
Cnr (Ibfm, Unit of Lecco, and Isti, Pisa) is partner of the NESTORE project (Non-intrusive empowering solutions and technologies for older people to retain everyday life activity) recently funded by the H2020 Programme under Strategic Challenge 1 'Health, demographic change and wellbeing' in response to the call on healthy ageing. NESTORE involves 16 partners from 8 European countries
The increase of lactate and EtOH in Tl-exposed cell cultures suggests significant alterations in energy metabolism. The experiments in HN9.10e cells herein described suggest the activation of an ancestral mechanism to survive hypoxia/mitochondrial impairment, a kind of “functional hypoxia”, in which the EtOH production is the key adaptation that allows a continued high level of glycolysis.
In summary the results of this research demonstrated a marked toxicity of Tl even at low doses (4.9, 49 and 490 nM) and for relatively short incubation times (48 h). Considering that Tl+1 rapidly distributes in the various body compartments competing with K+, our results should give an alert on the need of review the concentration limits of Tl in the environment and in the body fluids
Nanomedicine Rome 2018, as well as the previous editions, will be a meeting point to present and discuss the most recent achievements and the perspectives of nanotechnologies applied to medicine.
The newness connected to 2018 edition will be a school, Nanomedicine course Rome 2018, dedicated to young scientists and focused on some of the methods and tools exploited in Nanomedicine; the school will take place soon after the Conference on June 21 and will last one day