The Department of Biomedical Sciences manages the research activity in Biology, Medicine and Public Health. It provides technologies and services to both the public and the private area, with the purpose of promoting knowledge on the fundamental mechanism governing physiological and pathological aspects in living organism, starting from basic research in life sciences to the study of human diseases and of innovative therapeutic interventions. The ultimate aim is to explore new opportunities for ameliorating the health of mankind.
The fundamental activities regard oncology, neurodegenerative diseases, cardiovascular and pulmonary diseases, immunology and infectious diseases, epidemiology and health care research, Biology and biomedical technologies. In these areas, some technologies have been developed and they have found a wider use in the different benchmark areas: proteomics, pharmacogenomics, advanced calculus in bioinformatics and system biology, robotic systems for the limbs’ rehabilitation, molecular diagnostics and imaging.
Metabolic health also requires a good memory. A study coordinated by the Institute of biomolecular chemistry of the Cnr describes a functional alteration of the neuronal circuit that regulates episodic memory in a mouse model of obese subjects. This circuit links neurogenesis during obesity and can influence decision-making processes, including those related to food choices, from an early age. The study is published in Nature Communications
A team of researchers from Cnr-Ibbc Italy has identified the anti-neural aging role played by this molecule in vivo. The results are published in Frontiers in Cell and Developmental Biology
Italian researchers hypothesize that the resting brain, in the absence of particular tasks to perform, functions as a class of computational algorithms called 'generative models' and that the spontaneous activity it generates is necessary to optimize learning and the preparation to perform future tasks. The study, which involves Cnr, University of Padua, Irccs Ospedale San Camillo Venice, Padua Neuroscience Center and Veneto Institute of Molecular Medicine, is published in Trends in Cognitive Sciences
Several therapeutic strategies promoting cancer cell death have been developed and a wide range of cancer treatments is nowadays available. However, most of the conventional treatments do not selectively kill tumor cells and others suffer from tumor cells' heterogeneity, which makes it challenging to identify the appropriate targets. In this scenario, the identification of new drugs - or drug combinations - targeting well-known signaling pathways as well as the repurposing of approved drugs showing previously unexplored anti-tumor activities can provide a renewed spectrum of therapeutic options in oncology
SensApp: the European project towards a groundbreaking diagnostics for the Alzheimer's disease through a routine blood sample
The European project SensApp, coordinated by the Institute of Applied Sciences and Intelligent Systems of te CNR, towards a groundbreaking diagnostics for the Alzheimer’s disease through a routine blood sample. EU project SensApp brings together several scientific groups from across Europe to collaborate on the development of a super-sensor, which could enable a new, more humane way for Alzheimer’s disease discovery and continuous monitoring. Currently, preclinical detection of the disease requires a painful lumbar puncture to observe unusual protein levels in the patient’s cerebrospinal fluid
A pandemic is a natural catastrophic event, a gigantic, prolonged "earthquake": unpredictable, but with the certainty that sooner or later it will happen, yielding devastating health and socio-economic effects. What we are learning from the Covid-19 "earthquake"? The website promoted by the Department of Biomedical Sciences of the National Research Council of Italy (Cnr-Dsb) is facing some big questions about the SARS-CoV-2 pandemic
The Institute of neuroscience (In) of the National Research Council of Italy announces the upcoming meeting on "Nicotinic Acetylcholine Receptors: from Molecular Pharmacology to Behaviour", which will be held on December 13, 2021, as a tribute to the work of Cecilia Gotti.