The Department of Biomedical Sciences manages the research activity in Biology, Medicine and Public Health. It provides technologies and services to both the public and the private area, with the purpose of promoting knowledge on the fundamental mechanism governing physiological and pathological aspects in living organism, starting from basic research in life sciences to the study of human diseases and of innovative therapeutic interventions. The ultimate aim is to explore new opportunities for ameliorating the health of mankind.
The fundamental activities regard oncology, neurodegenerative diseases, cardiovascular and pulmonary diseases, immunology and infectious diseases, epidemiology and health care research, Biology and biomedical technologies. In these areas, some technologies have been developed and they have found a wider use in the different benchmark areas: proteomics, pharmacogenomics, advanced calculus in bioinformatics and system biology, robotic systems for the limbs’ rehabilitation, molecular diagnostics and imaging.
Recent advances in basic and clinical vision research have made ophthalmology one of the most exciting fields of technological and therapeutic innovations. The Symposium 'Restoration of Vision' aims at gathering together renown academia and industry experts to discuss the breakthroughs in vision restoration therapies
A new study has successfully established the first gene therapy approach to reduce or prevent a-synuclein toxic aggregates that are causing neuronal dysfunctions and loss in Parkinson’s disease. These results pave the way for testing gene therapy approaches for the treatment of neurodegenerative diseases that might affect also large brain areas. The study has been published in 'Molecular Therapy'
Different ways to recover a perturbed replication fork: implications for genome integrity and disease
Pietro Pichierri, from the Department of Environment and Health Istituto Superiore di Sanità, Rome, will give a seminar on the mechanims controlling the integrity of the human genome during DNA replication.
A research team at Isa-Cnr analyzed the use of these natural, antioxidant compounds in cancer, highlighting, in two studies, the pros and cons of their use and demonstrating that not always their effect(s) does depend upon the antioxidant activity. The articles have been published on Seminars in Cancer Biology and Oncotarget
A research team comprising the Institute of Sciences of Food Production Unit of Lecce (Ispa-Cnr) and the Institute of Crystallography of Bari of the National Research Council have determined for the first time the complete crystal structure of one of the main ERQC components, the checkpoint enzyme UDP-Glucose glycoprotein glucosyltranseferase (aka UGGT). See the article at Pubmed
A study published in the journal Pediatrics outlined the prospect of a new hereditary transmission mechanism of Incontinentia pigmenti disease. A team of researchers from the Institute of genetics and biophysics of Cnr of Naples with the Pediatric hospital Bambino Gesù and the University of Ferrara, discovered the novel forms of familiarity in Incontinentia pigmenti, by genetically characterizing the molecular alteration in somatic and germline cells of IP male father, although to date it was referring to the exclusive maternal inheritance
Through sophisticated metagenomics and bioinformatics techniques, italian researchers from the Cnr - Italian Research Council - and University of Florence characterized the bacterial and fungal gut microbiota in a cohort of autistic individuals. The study, pulished on ‘Microbiome’, underlines the importance of the microbiome as biomarker and therapeutic target, in dietary intervention studies for the improvement of the quality of life of ASDs patients