THERmoablation of Melanoma and mammary carcinoma with Injected NAnoplarticles coupled TO Radiotherapy (THERMINATOR) (DIT.AD002.133)
Thematic area
Engineering, ICT and technologies for energy and transportation
Project area
Nanotecnologie e materiali avanzati (DIT.AD002)Structure responsible for the research project
Institute of applied physics "Nello Carrara" (IFAC)
Project manager
FULVIO RATTO
Phone number: 0555225307
Email: f.ratto@ifac.cnr.it
Abstract
This project is based on the following data: ECFCs uptake AuNPs (AuNP-ECFC) and privilege homing within tumors. In contrast to what happens by injecting bare NPs, viable Au-ECFCs remain within tumors for several weeks. The accumulation and biodistribution of AuNP-ECFCs can be followed in vivo by the novel photoacoustic imaging (PAI), which allows to achieve maximun sensitivity and specificity for the detection of tumor mass and of macro/micro-metatases in experimental animal models. AuNP-ECFCs display excellent thermotransductive properties that kill cancer cells in vitro upon laser irradiation at moderate NIR light intensities and induce necrotization of experimental tumors in mice inoculated with AuNP-ECFCs. These results led to the patent n. 102016000045932 deposited on May 04th 2016.
Start date of activity
01/01/2020
Keywords
a, b, c
Last update: 02/08/2025