Institute of biomedical technologies (ITB)
Dott. GIANLUCA DE BELLIS
Phone number: 02 26422702
c/o Laboratorio Interdisciplinare di Tecnologie Avanzate (LITA)
Via Fratelli Cervi, 93 - 20054 Segrate (MI)
Phone number: 02 26422702 - 02 26422708
Fax: 02 26422770
The Institute is unique at national level in having a high level of expertise in the comprehensive application of omics methodologies (proteomics, genomics and bioinformatics) to study genetic, epigenomic and environmentally-induced human diseases. Advanced proteomics technologies are used for complex protein systems analysis in cells, tissues and biological fluids. State of the art next generation sequencing is applied to study DNA and RNA in human diseases and in pathogens. Bioinformatics deals with the investigation of algorithms for genomic and transcriptomic analyses, high performance computational technologies for drug design and Systems Biology and for developing new models dedicated to the study of cell cycle. A major objective of the Institute is to advance novel technologies to identify mechanisms of disease and establish novel therapeutic strategies for clinical applications. In oncology in order to understand the mechanisms of conversion of normal stem cells into cancer stem cells, the genes and pathways that control self-renewal of stem cells are investigated using human stem cells, cancer stem cells, induced pluripotent cells and mesenchymal stem cells, and their use in regenerative medicine. In neurodegenerative diseases the pathogenic mechanisms and epidemiology of Alzheimer, Parkinson and Multiple Sclerosis are investigated; moreover the mechanisms of brain aging involved in pathogenesis of these diseases are also studied. The Institute is also engaged in bioethics and research integrity, with special focus on neuroethics and medical ethics.