Institute of biomolecular chemistry (ICB)

Expertise

Here you will find only a few examples of experimental activities relevant to the mission of ICB and to its lines of research

i) study of marine natural products: structure, reactivity, biological functions and potential pharmacological applications;
ii) study of chemical signalling systems and lipid mediators at the basis of the mechanism of action of natural products from medicinal plants: functional activity and therapeutic potential of their pharmaceutical and nutraceutical modulation;
iii) design and synthesis of organic molecules of biotechnological interest also through the use of biocatalysis;
iv) identification, characterisation, structure-activity relationships and in silico design of enzyme and receptor modulators;
v) study of pharmacological chaperones for the treatment of genetic disorders: development of new drugs and identification of new targets;
vi) characterisation, production and applications of endo- and exo-polysaccharides, lipids and proteins from extremophile microorganisms;
vii) production of microbic and algal biomasses and technological valorisation of vegetable wastes for applications in the pharmaceutical, nutraceutical, agricultural and renewable energy sectors;
viii) development and application of new methodologies and protocols for the identification of new therapeutic molecular and new biomarkers of human diseases;
ix) development of molecular systems able to reach and selectively recognise pathologic targets relevant to human pharmacoresistance, cancer diagnostics and therapy, angiogenesis, etc., also through the use of nanotechnologies.

These activities are carried out through the use of new enabling technologies, such as:
o Mass spectrometry and nuclear magnetic resonance spectroscopy for:
      a) chemical and structural characterisation of organic molecules and peptides;
      b) metabolomic profiling of complex biological systems of biomedical interest.
o Computational methods for the modelling and molecular simulation of biomolecules and biocomplexes;
o FTIR spectroscopy in solution and solid state
o Fluorescence and MW modulated (ODMR) fluorescence spectroscopy
o Fermentation of extremophiles and microalgae, and chemical processing of vegetable biomasses
o Development of techniques for the quantitative analysis and profiling of chemical signals
o Structural studies by mans of X ray diffraction on single crystals
o Biophysical techniques for the study of peptide-protein and peptide-membrane interactions (Nilia-CD)
o Innovative chromatographic methods for the separation of enantiomers
o Morphological analysis of protein profiles in animal tissues by means of immunofluorescence and electron transmission microscopy
o Genomic and transcriptomic analysis of animal and human tissues for biomedical applications