The Institute of Molecular Biology and Pathology (IBPM) pursues cutting-edge research on complex biological processes with a highly multidisciplinary view. Multidisciplinarity, IBPM's distinctive feature and strength, reflects the integration of scientific and methodological expertise from a wide range of disciplines.
The multidisciplinary character of IBPM dates back to its establishment, in 2003, as a merger of three CNR research centers based at the University Sapienza of Rome, i.e.: the Center for Molecular Biology, started in 1965 by Prof. A. Rossi Fanelli; the Center for Evolutionary Genetics, started in 1969 by Prof. G. Montalenti; and the Center for Nucleic Acids, started in 1970 by Prof. G. Tecce. A group of researchers formerly at the CNR Institute of Biomedical Technologies (ITB) also joined IBPM. In 2013, a unit from the CNR Institute of Biomolecular Chemistry (ICB) also joined the institute, bringing to IBPM the expertise for in-house design and synthesis of relevant molecules. The history and evolution of IBPM exemplify the development of modern biology, with the development of integrated, cross-fertilizing approaches to address the complexity of physiological and pathological processes in living organisms.
Major research areas at IBPM cover the design and synthesis of bioactive compounds, the characterization of macromolecules and cellular systems, and a wide range of genetic and molecular studies on animals and plants, including engineered organisms. IBPM has achieved important results in several fields: structure and function of nucleic acids and proteins, genetic and epigenetic mechanisms regulating gene expression and genome organization, control of cellular differentiation and division, immune response, and interaction between organisms and the environment. Research efforts are also directed towards developing biotechnological and nanotechnological applications relevant to the fields of human health, environment, and agrifood.
The location of IBPM laboratories within La Sapienza University offers opportunities for delivering education and training at various levels, from academic teaching to pre- and post-doctoral research training, as well as fostering collaborations and scientific synergies with several University departments.