ERA4TB (DIT.AD021.106)
Thematic area
Engineering, ICT and technologies for energy and transportation
Project area
Matematica Applicata (DIT.AD021)Structure responsible for the research project
Institute for applied mathematics "Mauro Picone" (IAC)
Project manager
PAOLO TIERI
Phone number: 0649937349
Email: p.tieri@iac.cnr.it
Abstract
The European Tuberculosis Regimen Accelerator (ETBRA) has the explicit goal of developing a new combination therapy to treat all forms of TB starting from ~20 leads and drug candidates provided by EFPIA. Since details of these are as yet unavailable, we will implement an agile drug development algorithm that entails profiling and portfolio construction. Profiling involves characterisation and ranking molecules in preclinical studies comprising in vitro drug combination assays, hollow fiber and single cell analysis, innovative murine and non-human primate models, PK/PD studies, combined with biomarker discovery and non-invasive NIR or PET/CT imaging to monitor disease progression and response to treatment. Modelling, simulation and artificial intelligence tools will help progress compounds from early preclinical to clinical development and to predict drug exposure, human doses and the best combinations. After extensive preclinical profiling, selected compounds will enter portfolio development for first time in human tests and phase I clinical trials in order to ensure that they are safe, well-tolerated and bioavailable with negligible drug-drug interactions. If needed, formulation s
Goals
sviluppo ed implementazione di modellistica avanzata per il trattamento della tubercolosi.
Start date of activity
01/01/2020
Keywords
modellistica, tubercolisi
Last update: 25/04/2024