Cardiac Troponins and Heart Failure (carTn-HF) (DSB.AD006.239)

Thematic area

Biomedical sciences

Project area

Structure responsible for the research project

Institute of clinical physiology (IFC)

Project manager

CHIARA CASELLI
Phone number: 050 3153229
Email: chiara.caselli@ifc.cnr.it

Abstract

This study could provide insights into the molecular changes that occur in cardiac tissue in both HF pediatric and adult patients. It is unclear if these mechanisms are the cause or the effect of the failing heart, but they could represent a possible future therapeutic targets (Movassagh M, et al 2011; Sabia C, et al 2017). In particular, the deregulation in the expression of specific miRNAs associated to myocardial dysfunction led to develop research for the application of antagomir-based therapy in the patients with HF (van Rooij E and Kauppinen S 2014). Thus, results from this study could allow to assess whether these molecules can be useful for diagnosis and prognosis in the current clinical setting for patients with HF, also addressing for a personalized management and a targeted therapy.

Goals

This study could provide insights into the molecular changes that occur in cardiac tissue in both HF pediatric and adult patients. It is unclear if these mechanisms are the cause or the effect of the failing heart, but they could represent a possible future therapeutic targets (Movassagh M, et al 2011; Sabia C, et al 2017). In particular, the deregulation in the expression of specific miRNAs associated to myocardial dysfunction led to develop research for the application of antagomir-based therapy in the patients with HF (van Rooij E and Kauppinen S 2014). Thus, results from this study could allow to assess whether these molecules can be useful for diagnosis and prognosis in the current clinical setting for patients with HF, also addressing for a personalized management and a targeted therapy.

Start date of activity

01/01/2019

Keywords

heart failure

Last update: 25/05/2025