MoSES - Modelling Shock in the Experimental Setting (DIT.AD021.082)
Project areaMatematica Applicata (DIT.AD021)
Structure responsible for the research project
Systematic experiments are being conducted in Israel (Institute for Research in Military Medicine, Hadassah Jerusalem) with the intent of accumulating a wealth of data, which can be remotely acquired from the field and which can be rapidly analyzed by means of appropriate mathematical and computer models. Analysis of such data using math modelling tools would result in the development of algorithms capable of predicting physiological status and outcome at several stages of haemorrhagic shock, identifying potential therapeutic countermeasures and assessing the probability of their efficacy. The goal of the present project is to allow Israeli experimentalists and Italian biomathematicians to jointly develop complete, calibrated, validated models for human hypovolemic shock, which can be quickly, remotely tailored onto injured humans. These models, implemented in software, will form the basis for a medical Decision Support System, geared towards improving expected survival in groups of military or civilian trauma victims.
The first and most immediate threat to the life of a trauma victim, whether through a car accident or a gunshot wound, is the establishment of a deep and progressive state of hypovolemic shock, due to internal or external bleeding. The probability of success in dealing with recipients of this type of injuries depends on the prompt identification of the degree and rate of development of the lesion, as well as on the availability of therapies at the location of the victim. The need to rapidly and accurately assess the state of the patient is made more acute when the victims are several, in a possibly remote or hard-to-access location, and the immediately available therapeutic resources (blood, liquids, extrication equipment, rapid evacuation) are limited: in this case, it is essential that the medical decision maker be given the best possible information upon which to base triage and prioritization.
Start date of activity
human hypovolemic shock, Decision Support System, trauma
Last update: 08/12/2023