Grant Agreement n. 801126 -- EDIT H2020-FETOPEN-2016-2017 (DSB.AD008.446)

Thematic area

Biomedical sciences

Project area

Structure responsible for the research project

Institute of clinical physiology (IFC)

Project manager

LUCA MENICHETTI
Phone number: 0503152216
Email: luca.menichetti@ifc.cnr.it

Abstract

Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse andprogression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless followup,with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public healthprograms crave for early BCa detection protocols, to improve performance in the management of this devastatingdisease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolutionultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors.EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods(GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform.

Start date of activity

01/10/2018

Keywords

a, b, c

Last update: 10/12/2023