Grant Agreement n. 801126 -- EDIT H2020-FETOPEN-2016-2017 (DSB.AD008.446)
Project areaTecnologie Applicate alle Scienze Biomediche (DSB.AD008)
Structure responsible for the research project
Unmet clinical needs in the management of bladder cancer (BCa) are the prevention of tumor onset, relapse andprogression, and therapy of the aggressive carcinoma in situ (Cis), requiring weekly treatments and endless followup,with a consequent poor quality of life and the highest cost per patient among all cancers. Therefore, public healthprograms crave for early BCa detection protocols, to improve performance in the management of this devastatingdisease. Here we propose an advanced transformative technology termed EDIT combining a novel high-resolutionultrasound elastography and photoacoustic imaging on the bladder instilled with targeted plasmonic gold sensors.EDIT approach exploits the structural and mechanical properties of the bladder extracellular matrix (ECM) as a unique biomarker of the early onset/progression/relapse of carcinoma, through engineered novel gold nanorods(GNRs) used as intravesical photoacoustic antennas targeted at the ECM, generating an ad hoc visualization platform.
Start date of activity
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Last update: 10/12/2023