Expertise

Genomics and Transcriptomics

• Next Generation Sequencing (WGS, WES, RNASeq, single-cell RNASeq)
• Genotyping and targeted validation
• Analysis of tissue, blood, and liquid biopsy samples
• High-reliability platforms: Illumina and Ion Torrent

Clinical Cohorts and Data Management

• Collection and characterization of Clinical Cohorts
• Integration of Clinical, Phenotypic and Biometric Data
• Dedicated databases and data quality control

Biomarkers and Clinical Chemistry

• Biomarker Quantification: ELISA, xMAP, SiMoA
• Clinical Chemistry Analysis and Immunological Assays
• Biological and Translational Characterization Support

Cytometry and Immunophenotyping

• Multiparametric Flow Cytometry and Cell Sorting
• Study of Cellular Heterogeneity and Immune Activation
• Integration with Multi-omics Analysis

Bioinformatics and Biostatistics

• Analysis of large genomic, transcriptomic, proteomic, and metabolomic datasets
• Genetic association studies (GWAS) and variant interpretation
• Advanced statistical models, machine learning, and deep learning

Functional studies and experimental models

• Gene expression analysis and molecular networks
• In vitro cellular models: cell lines, primary cells, iPSCs, organoids
• Proteomics and biochemical analyses for the study of pathways and post-translational modifications

Molecular Oncology and Precision Medicine

• Solid Tumor Analysis and Liquid Biopsy
• Identification of Predictive and Prognostic Biomarkers
• NGS, ddPCR, EasyPGX, Idylla, FISH, and Immunohistochemistry Techniques

Genome Editing and Gene Therapy

• CRISPR-Cas9 for Experimental Models and Functional Studies
• Applications in Rare Diseases, Gene Therapy, and Regenerative Medicine

In Vivo Studies

• Transgenic and Knockout Mouse Models
• Analysis of Systemic Pathogenic Mechanisms
• Studies on ²-thalassemia, sickle cell anemia, and rare genetic diseases

Molecular Modeling and Drug Discovery

• Molecular docking, molecular dynamics, and virtual screening
• In silico design and optimization of RNA molecules and drugs
• Evaluation of interactions with biological targets and pharmacological properties