A joint study between IFOM (FIRC Institute of Molecular Oncology) in Milan and the Institute ofg Molecular Genetics - National Research Council (IGM-CNR) of Pavia, with the support of AIRC and Telethon, published in Cell, confirms the key role of senataxina in regulating the process of transcription and replication of DNA. Its mutation affects two serious neurodegenerative diseases and may play a role in cancer formation.
Reference: Chiara Lucca, Daniele Piccini, Walter Carotenuto, Marco Saponaro, Alessandra Brambati, Andrea Cocito, Marco Foiani, Giordano Liberi. Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II Transcribed GenesAmaya Alzu, Rodrigo Bermejo, Martina Begnis, Cell, Volume 151, Issue 4, 835-846, 9 November 2012
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