Sea Urchin innate immunity and NanoSafETv (SUNSET) (DSB.AD001.187)
Area tematica
Area progettuale
Oncologia e Immunologia (DSB.AD001)Struttura responsabile del progetto di ricerca
Istituto di Farmacologia Traslazionale (IFT)
Altre strutture che collaborano al progetto di ricerca
Responsabile di progetto
ANNALISA PINSINO
Telefono: 0916809557
E-mail: annalisa.pinsino@irib.cnr.it
Abstract
The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how organisms interact with NM by either mounting a defensive response or by physiologically adapting to them. The interaction of NM with one of the major biological system deputed to the recognition of and responses to foreign challenges, i.e., the immune system, need to be addressed. However, the NM immune-compatibility remains an open issue, even for ethical reasons. The survey of the sea urchin genome has disclosed strong similarities between sea urchin and human innate immune-related genes, and also provides clues of alternative adaptive or anticipatory immune functions that are shared with humans.For these reasons, the sea urchin can be considered an excellent proxy for human model for investigating the nano-immune interaction in vivo and, more recently, also in vitro.
Obiettivi
SUNSET project aims on the understanding of the biosafety of nanoparticles and nanoplastics in the emergent proxy to human non-mammalian model for in vivo and vitro basic and translational immunology, the sea urchin Paracentrotus lividus, focusing on cell regulation, signalling, and differentiation mechanisms involved in innate immune defence, innate memory and immunological ageing.
Data inizio attività
01/01/2021
Parole chiave
Sea Urchin, Immunity, Nanosafety
Ultimo aggiornamento: 03/05/2024