REDTEAR - H2020 (MSCA-IF-EF-ST)(VERBANIA) (DTA.AD002.661)

Area tematica

Scienze del sistema Terra e tecnologie per l'ambiente

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di ricerca sulle acque (IRSA)

Responsabile di progetto

ANDREA DICESARE
Telefono: 0323 518300
E-mail: andrea.dicesare@irsa.cnr.it

Abstract

Free extracellular DNA (FED) is DNA dissolved in waters and in soils, where it arrives after being excreted by living organisms or following the disruption of living cells. FED can be the most prominent fraction of DNA in waters subjected to strong disturbances, where the mortality rate of microorganisms is high, e.g. wastewater treatment plants effluents. FED are composed by a variety of DNA fragments including resistance genes and mobile elements. There are early evidences than FED can represent a very important, although neglected, source of antibiotic resistance genes (ARGs) in the environment, where the bacterial community can access FED and incorporate extracellular DNA by horizontal gene transfer.If this process will be confirmed and quantified by dedicated researches, our understanding of the cycle of antibiotic resistances into the environment and back to human pathogens could change dramatically, calling for a whole rethinking of the wastewater treatments nowadays applied. The Project REDTEAR will tackle the issue and will clarify the role of FED in the spread and the persistence of ARGs in open waters in central Europe.

Data inizio attività

01/10/2021

Parole chiave

REDTEAR, MARIE CURIE, ANTIBIOTIC RESISTOME

Ultimo aggiornamento: 23/04/2025