ROLE OF OTTABAC IN A MOUSE MODEL OF IRRITABLE BOWEL SYNDROME (IBS) INDUCED BY STRESS (DSB.AD004.346)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Biochimica e Biologia Cellulare (IBBC)

Responsabile di progetto

STEFANO FARIOLIVECCHIOLI
Telefono: 0690091
E-mail: stefano.fariolivecchioli@cnr.it

Abstract

Maternal separation (MS), early in life, has a profound effect, also in adulthood, on gastrointestinal functions and has been described as a model of gut-brain axis dysfunction suitable for the study of disorders such as irritable bowel syndrome (IBS). MS in rodents constitutes a well-established model of alterations in the gut-brain cross-talk induced by early life trauma, resembling chronic psychological stress in humans. Compared to control animals, MS rodents show higher corticosterone levels, both in basal conditions and in response to subsequent stress, gastrointestinal dysfunction (increased motility or visceral/colonic sensitivity), increased intestinal permeability and inflammatory markers in the gut (e.g. myeloperoxidase activity) or in peripheral blood (e.g. TNF-a, IL-6 secreted by blood cells stimulated ex vivo), and bacterial translocation. MS also leads to anxiety and a depression-like phenotype associated with alterations in brain biochemistry.
In this project we will evaluate the effect of 15-days administration of the probiotic OttaBac in adult mice that underwent maternal separation from postnatal day 2 to day 14. At the end of the treatment with the probiotic w

Data inizio attività

30/03/2021

Parole chiave

Maternal Separation, Gut-Brain axis, Probiotics

Ultimo aggiornamento: 04/05/2024