BOW: Biogenic Organotropic Wetsuits (DSB.AD008.639)
Area tematica
Area progettuale
Tecnologie Applicate alle Scienze Biomediche (DSB.AD008)Struttura responsabile del progetto di ricerca
Istituto per la Ricerca e l'Innovazione Biomedica (IRIB)
Altre strutture che collaborano al progetto di ricerca
- Istituto di biofisica (IBF)
- Istituto di Bioscienze e Biorisorse (IBBR)
- Istituto per lo studio dei materiali nanostrutturati (ISMN)
Responsabile di progetto
ANTONELLA BONGIOVANNI
Telefono: 0916809554
E-mail: antonella.bongiovanni@irib.cnr.it
Abstract
Extracellular vesicles (EVs) are the universal shuttles of intercellular communication, transferring lipids, proteins and nucleic acids, mediating physiological processes and spreading various diseases, including cancer and infections. The main goal of the EU-funded BOW project is to explore and develop the technology capable of lending the biological surface precision, circulation and targeting abilities of EVs to superparamagnetic nanodevices by coating them with a single- or multi-layer EV membrane. This technology aims to advance implantable nanodevices and nanomaterials towards sustainable production and clinical translation, proving the possibility of recapitulating biomimetic functions on any synthetic nanodevice.
Obiettivi
The main goal of the BOW project is to explore and consolidate the technology able to impart biological surface precision, circulation and targeting abilities of EVs to superparamagnetic nanodevices by "dressing" them with a single- or multi-layer "wetsuit" of EV membrane "fabric". This will proof and set a general, viable paradigm to recapitulate key biomimetic functions - including camouflage to the immune system and organ site/tumor targeting - to any synthetic nanodevice, while being disruptive as a first example of biogenic nanotechnology. Major objectives include: (i) production high-grade EVs with biomimetic and organotropic functions, (ii) synthesis and functionalization of MBDs, (iii) engineering a microfluidic device for streamlined fabrication of EV membrane coated MBDs (evMBDs) (iv) evaluation of evMBD biological performances and nanotoxiciy in-vitro, ex-vivo and in-vivo. BOW will be made possible thanks to well-established and internationally recognized academics (7), high biotech SMEs (3), plus 1 innovation consulting, contributing to strengthen European pool of expertise and biotechnology innovation eco-system.
Data inizio attività
01/11/2020
Parole chiave
Extracellular Vesicles, Biomimetic Nanoparticles, Nanotechnology
Ultimo aggiornamento: 25/04/2024