Multifunctional Polymeric Cyclodextrin Nanocarriers As Novel Triple-Negative Breast Cancer Treatment: A Versatile Photo-Chemotherapy Bypassing Hypoxic Conditions -- HypoCyclo (DCM.AD004.113)
Area tematica
Scienze chimiche e tecnologie dei materiali
Area progettuale
Chimica verde e processi per la sostenibilità (DCM.AD004)Struttura responsabile del progetto di ricerca
Istituto per la sintesi organica e la fotoreattività (ISOF)
Responsabile di progetto
ROBERTO ZAMBONI
Telefono: 0516399770
E-mail: direzione@isof.cnr.it
Abstract
Seeking for innovative Triple Negative Breast Cancer (TNBC) therapies, HypoCyclo aims at the optimal combination of chemotherapy and photodynamic therapy (PDT). We envisage novel, tailored cyclodextrin (CyD)-based polymeric nanoparticles (NPs) able to load "known" therapeutic agents and decorated with a photosensitizer as well as an Oxygen-Releasing Agent (ORA). HypoCyclo focuses on the very effective drug paclitaxel (PCX) presenting several treatment problems like water insolubility. The polymers are expected to solubilize and encapsulate PCX in order to implement PCX chemotherapy with PDT, through the decoration with a PS able to generate antitumor reactive oxygen species (ROS) in situ. As hypoxia in TNBC compromises standard chemotherapy and PDT, we will tailor our NPs with an ORA able to release oxygen in cells, enabling an alternative ROS source. The PCX loaded NPs will be completely characterized and tested in 2D and 3D TNBC models. Our goal is to keep the synthetic protocols simple, low-cost and green to facilitate industrial upgrade of the loaded multimodal NPs endowed with improved in vitro efficacy.
Obiettivi
Our project aims at the combination of chemotherapy with photodynamic therapy (PDT) in optimized conditions for the selective and effective treatment of TNBC. We envisage novel tailored cyclodextrin (CyD)-based polymeric NPs able to load PCX and decorated with a photosensitizer (PS) as well as a newly synthesized oxygen releasing agent (ORA). Our goal is to keep the synthetic protocols simple, low-cost and green, in order to facilitate industrial upgrade of NPs endowed with excellent stability, massive loading and improved in vitro efficacy
Data inizio attività
01/09/2020
Parole chiave
cyclodextrin-based polymers, photodynamic therapy, hypoxia
Ultimo aggiornamento: 06/07/2025