Research project

ROLE OF OTTABAC IN A MOUSE MODEL OF IRRITABLE BOWEL SYNDROME (IBS) INDUCED BY STRESS (DSB.AD004.346)

Thematic area

Biomedical sciences

Project area

Neuroscienze (DSB.AD004)

Structure responsible for the research project

Istituto di Biochimica e Biologia Cellulare (IBBC)

Project manager

STEFANO FARIOLIVECCHIOLI
Phone number: 0690091
Email: stefano.fariolivecchioli@cnr.it

Abstract

Maternal separation (MS), early in life, has a profound effect, also in adulthood, on gastrointestinal functions and has been described as a model of gut-brain axis dysfunction suitable for the study of disorders such as irritable bowel syndrome (IBS). MS in rodents constitutes a well-established model of alterations in the gut-brain cross-talk induced by early life trauma, resembling chronic psychological stress in humans. Compared to control animals, MS rodents show higher corticosterone levels, both in basal conditions and in response to subsequent stress, gastrointestinal dysfunction (increased motility or visceral/colonic sensitivity), increased intestinal permeability and inflammatory markers in the gut (e.g. myeloperoxidase activity) or in peripheral blood (e.g. TNF-a, IL-6 secreted by blood cells stimulated ex vivo), and bacterial translocation. MS also leads to anxiety and a depression-like phenotype associated with alterations in brain biochemistry.
In this project we will evaluate the effect of 15-days administration of the probiotic OttaBac in adult mice that underwent maternal separation from postnatal day 2 to day 14. At the end of the treatment with the probiotic w

Start date of activity

30/03/2021

Keywords

Maternal Separation, Gut-Brain axis, Probiotics

Last update: 25/04/2024