PRIN 2017 - 2017CBHCWF - Luigi Ambrosio (DCM.AD007.096)
Thematic area
Chemical sciences and materials technology
Project area
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Structure responsible for the research project
Institute of Polymers, Composites and Biomaterials (IPCB)
Other structures collaborating in the research project
Project manager
LUIGI AMBROSIO
Phone number: +0812425929
Email: luigi.ambrosio@cnr.it
Abstract
SAPIENT will aim to elucidate the mechanical, structural, chemical and biological implications of collagen-glucose interactions over the full range of (patho-)physiological glucose concentrations. To this end,
we have assembled leading groups in the areas of materials science, polymer, medicine together with excellent tissue engineering facilities to generate relevant murine and human tissue analogues, and
mouse models. This partnership will deliver enhanced tools for investigating collagen-sugar interactions across molecular, fibril, engineered tissue matrix to ex vivo and in vitro models. The detail of the molecular, structural and biological interactions will be studied across length scales from atomic through nano and micro to macro, providing for the first time a comprehensive set of tools and more complete
understanding of glycation and their roles in the (patho-)physiology of animals and humans.
Start date of activity
14/09/2019
Keywords
biomaterials, tissue engineering, bioprinting
Last update: 25/04/2024