PRIN2017-20175XBSX4_006-Davide Pirolli (DCM.AD007.090)
Thematic area
Chemical sciences and materials technology
Project area
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Structure responsible for the research project
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC)
Other structures collaborating in the research project
Project manager
DAVIDE PIROLLI
Phone number: 06301551535
Email: davide.pirolli@cnr.it
Abstract
In recent years, the Hedgehog (Hh) pathway has emerged as the most promising target for the development of anticancer drugs. A variety of Smo antagonists have been developed but their clinical use has failed due to different issues such as pharmacokinetics and the emergence of drug resistance. For this reason, the discovery of new effective Hh inhibitors is needed. The present project will be devoted to the modulation of the Hh signaling pathway by new chemical entities (NCE) designed by coupling synthetic feasibility criteria with pharmacophoric and steric features. In particular, this ambitious proposal would lead to selection, priorization and optimization of new classes of compounds by a ligand-based molecular modeling or strusture-based approaches and their synthesis through innovative and sustainable chemical processes, a priority of modern chemistry. Furthermore, the study will be aimed at developing of suitable delivery technologies in order to provide a viable alternative for cancer therapy.
Start date of activity
29/10/2019
Keywords
drug discovery and design, structural biology and crystallography, green chemistry
Last update: 20/04/2024