Light induced cell control by exogenous organic semiconductors (DFM.AD003.323)
Thematic area
Physical sciences and technologies of matter
Project area
Materiali innovativi (DFM.AD003)Structure responsible for the research project
Istituto di cibernetica "Edoardo Caianiello" (ISASI)
Project manager
CLAUDIA TORTIGLIONE
Phone number: 0818675306
Email: claudia.tortiglione@isasi.cnr.it
Abstract
The identification of new materials capable to optically regulate cell activity is an extremely hot topic. Organic semiconductors are ideal candidates, since they are inherently sensitive to visible light and highly biocompatible, sustain both ionic and electronic conduction, can be functionalized with biomolecules and drugs. This project aim to develop new devices and materials to control stem cell differentiation and tissue regeneration. As model organism both Hydra vulgaris and cell lines will be used to test biocompatibility and bioactivity of the newly designed organic compounds
Goals
The project aims to test the biocompatibility and bioactivity of organic semiconductor materials using an invertebrate animal, the freshwater polyp Hydra vulgaris, presenting unique regenerative potential. Photostimulation of semiconductior material of different shapes and geometries, following internalization in Hydra tissues, will be tested using a variety of approaches, from in vivo behavioural tests, up to cell and molecular biology analyses
Start date of activity
11/04/2019
Keywords
photovoltaic materials, photostimulation, model organism
Last update: 28/03/2024