SCREENED - A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner. (DCM.AD007.057)
Thematic area
Chemical sciences and materials technology
Project area
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Structure responsible for the research project
Institute of science and technology for ceramics (ISSMC)
Project manager
MONICA SANDRI
Phone number: 0546/699761
Email: monica.sandri@istec.cnr.it
Abstract
SCREENED will develop 3 different three-dimensional in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach.
These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions.
Goals
ISTEC is involved to develop new superparamagnetic biocompatible and biomimetic particles that will be used to produce "magnetic cells" to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs.
Start date of activity
01/12/2018
Keywords
Bioceramic, magnetic nanoparticles, magnetic cells
Last update: 04/12/2024