INCIPIT-INtegrated Conductive and biomimetic polymeric Interfaces able to serve as micronanostructured Patches for myocardIal regeneraTion (DCM.AD007.025)
Thematic area
Chemical sciences and materials technology
Project area
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Structure responsible for the research project
Institute for chemical and physical processes (IPCF)
Project manager
CATERINA CRISTALLINI
Phone number: 0502217802
Email: caterina.cristallini@cnr.it
Abstract
The leading cause of death for cardiovascular disease is coronary herat disease. Current therapies do not restore the functionality of damaged myocardial tissue. The only effective therapeutic intervenction is an approach able to stimulate the autonomous regeneration of myocardium. Recently we developed bioartificial scaffolds with the potential to serve as acellular patches for in vivo cardiac regeneration. Herein, the patch will be implemented with electroconductive polymers in order to improve cardiac commitment. The protection against ventricular remodelling and recruitment of stem cells in situ will be pursued through nanotechnologies. The therapeutic product will be validated in vitro using stem and precursor cells, induced pluripotent stem cells, organotypic heart cultures and in vivo using a small model. The INCIPIT cardiac patch technology will move this material-based product closer to the market of smart therapies in the cardiovascular field.
Goals
The specific objectives of this project will be addressed to:
micro-nanostructured polymeric patches;
advanced in vitro validation;
in vivo implant;
translation strategy.
Start date of activity
29/01/2018
Keywords
patch, myocardial, regeneration
Last update: 27/04/2025