AIRC COLOMBO 2018-2022 (DCM.AD007.022)
Thematic area
Chemical sciences and materials technology
Project area
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Structure responsible for the research project
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC)
Project manager
GIORGIO COLOMBO
Phone number: 0228500031
Email: giorgio.colombo@icrm.cnr.it
Abstract
To meet these challenges we aim to: 1) Computationally optimize, synthesize and validate in vivo novel leads that allosterically modulate Hsp90 functional motions and induce cancer cell death through different mechanisms than ATP-competitive drugs. 2) Develop integrative computational methods to elucidate the key determinants of Hsp90 recognition, and translate this information into the evolution of chemical tools targeting select PPIs. 3) Map the effects of designed molecules on physiological assemblies in vitro and in vivo, and evaluate synergistic effects with known drugs in the context of drug-resistant cell lines.
Start date of activity
01/01/2018
Keywords
Protein-Protein Interactions, Drug Discovery, Cancer Chaperones
Last update: 24/04/2025