FIRB2010 (DSB.AD006.083)

Thematic area

Biomedical sciences

Project area

Structure responsible for the research project

Istituto di Biochimica e Biologia Cellulare (IBBC)

Project manager

CHIARA LANZUOLO
Phone number: 3297429357
Email: chiara.lanzuolo@cnr.it

Abstract

The Polycomb group (PcG) of proteins is part of a conserved epigenetic cell memory system that prevents changes in cell lineage identity by maintaining
transcription patterns through cell divisions via chromatin structure. Although it is clear that chromatin organization and histone methylation are altered in diseases
caused by mutant lamins, virtually nothing is known about the specific functions of lamins in these processes under normal physiological conditions. We hypothesize
an involvement of lamin in the coordination of gene expression regulating contemporary sub-set of genes throughout direct or indirect interactions with Polycomb
complexes. Physiological processes such as differentiation and senescence and pathological conditions as premature senescence and lamin disorders will be
investigated. The novelty of this project is a new approach to nuclear scaffold research with tools that will explore the epigenetic aspect of lamin function.

Goals

Identificazione e caratterizzazione dei meccanismi molecolari alla base della distrofia muscolare di Emery Dreifuss

Start date of activity

08/03/2012

Keywords

epigenetics, polycomb, lamin

Last update: 08/06/2025