Seminario "Replication stress and chromosomal instability as a driver of accelerated aging in RECQ and related helicase disorders"

Il 30/06/2023 ore 14.30 - 15.30

Seminar room Cnr-Ibbc
Via Pietro Castellino 111
Area di ricerca di Napoli 1

Roles of DNA Helicases in Genomic Stability: Genetic mutations in a class of molecular motor proteins known as helicases are linked to a growing number of human disorders, indicating that these enzymes have vitally important roles during replication, DNA repair, recombination and transcription. The focus of Brosh group is genetic diseases frequently associated with premature aging, cancer, and/or mitochondrial dysfunction arising from genetic variations in genes encoding DNA helicases that operate uniquely in pathways of DNA repair and the replication stress response. A special topic of interest is the application of small molecules to modulate helicase activity as a tool to assign specific helicase functions in vivo and potential development of therapeutic strategies.

Speaker is prof. Robert M. Brosh jr. (NIA-NIH, Baltimore, Usa).

Organizzato da:
CNR - Istituto di Biochimica e Biologia Cellulare

Referente organizzativo:
Francesca M. Pisani
CNR - Istituto di Biochimica e Biologia Cellulare
Via Pietro Castellino n.111 Napoli- Area di ricerca NA 1 Napoli
francesca.pisani@ibbc.cnr.it

Modalità di accesso: ingresso libero