Targeting early disease' mechanisms in neurodegenerative disorders
Il 19/07/2019 ore 12.00 - 13.00
Area della Ricerca Na1 (sala conferenza), Via Pietro Castellino 111, 80131 Napoli
Elvira De Leonibus, PhD (from the Institute of cellular biology and neurobiology 'ABT' [Cnr-Ibcn], Monterotondo Scalo, Roma & the Telethon Institute of Genetics and Medicine [TIGEM], Pozzuoli) will give a seminar on 'Targeting early disease’ mechanisms in neurodegenerative disorders'.
Neurodegenerative diseases are debilitating and largely untreatable conditions. Most of them, such as Parkinson’ and Alzheimer’ disease, are strongly linked with age; inherited neurodegenerative lysosomal storage disorders, such as mucopolysaccharidosis type III (MPS-IIIA), manifest during childhood.
One of the biggest challenges, to fight neurodegenerative disorders, is the identification of early signs of the pathology and associated disease’ mechanisms leading to neuronal loss to develop restorative or protective therapeutic approaches.
The seminar will show how to address this challenge with a novel approach that uses early discrete behavioural dysfunctions to pinpoint synaptic and molecular disease’ mechanisms, while accounting for their intrinsic heterogeneity in the complex and evolving phenotypes of neurodegenerative disorders. This approach allowed to identify completely novel disease’ pathways in Parkinson’ disease and MPS-IIIA and how this approach permits the “repositioning” of treatments among different neurodegenerative and other chronic diseases.
Organizzato da:
Istituto di biochimica e biologia cellulare
Referente organizzativo:
Daniela Corda
Cnr-Ibbc
Via Pietro Castellino 111, 80131 Napoli
d.corda@ibp.cnr.it
081 613536
Modalità di accesso: ingresso libero
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