Structure and function of phospholipid transfer proteins

Il 08/11/2018 ore 12.00 - 13.00

Sala Conferenze Cnr, Area della Ricerca Na1, Via P. Castellino, 111 80131 Napoli

Karel WA Wirtz from the Institute of Biomembranes, Utrecht University, the Netherlands, will give a seminar on phospholipid transfer.

Since their discovery and subsequent purification from mammalian tissues more than 30 years ago an impressive number of studies has been carried out to characterize and elucidate the biological functions of phosphatidylcholine transfer protein (PC-TP), phosphatidylinositol transfer protein (PI-TP) and non-specific lipid transfer protein, more commonly known as sterol carrier protein 2 (SCP-2). Wirtz will present information to show that these soluble, low-molecular weight proteins constitute domain structures in StArR-related lipid transfer (START) proteins (i.e. PC-TP), in retinal degeneration protein, type B (RdgB)-related PI-TPs (e.g. Dm RdgB, Nir2, Nir3) and in peroxisomal beta-oxidation enzyme-related SCP-2 (i.e. 3-oxoacyl-CoA thiolase, also denoted as SCP-X and the 80-kDa D-bifunctional protein). Further he will summarize the most recent studies pertaining to the physiological function of these soluble phospholipid transfer proteins in metazoa.

See also review FEBS Lett. 2006 Oct 9;580:5436-41

Organizzato da:
IBP, Cnr

Referente organizzativo:
Daniela Corda
Cnr - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
d.corda@ibp.cnr.it
081/6132536

Modalità di accesso: ingresso libero