On the fight between cytotoxic T lymphocytes and cancer cells at the lytic synapse
Il 17/09/2018 ore 14.30 - 15.30
Sala Conferenze, Area della Ricerca CNR Na1. Via P. Castellino, 111 Napoli
Dr Salvatore Valitutti, from INSERM, Cancer Research Center of Toulouse (France) will give a seminar on the lytic synapses formed by human cytotoxic T lymphocyte (CTL) when interacting with target cells. His group has a long-standing interest in the study of the molecular composition, dynamics and function of immunological synapses formed between cells of the human immune system.
In the first part of his talk, he will summarize our contribution to the field of human CTL biology and in particular to the notion of the high sensitivity, rapidity and efficacy of CTL responses. He will introduce the concept of lytic versus stimulatory synapse dichotomy in human CTLs and he will illustratate how this concept evolved on the basis of our recent findings on the heterogenous killing behaviors of individual CTLs.
In the second and main part of the talk, Dr valitutti will expose our recent findings on the molecular mechanism of human CTL-mediated cytotoxicity by describing the events occurring on both sides of the CTL/target cell lytic synapses during the very early moments of cell-cell interaction. he will discuss: i) how extremely rapid steps of lytic granule secretion occur at the lytic synapse and ii) how melanoma cells defend themselves from the CTL attack at the lytic synapse via the rapid secretion of their lysosomes.
Throughout his presentation, Dr Valitutti will discuss how the measurement of [Ca2+]i increases in both CTL and their target cells is a key readout to study the early steps of CTL-mediated cytotoxicity at the lytic synapse.
Organizzato da:
Ibp, Cnr
Referente organizzativo:
Daniela Corda
Cnr - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
d.corda@ibp.cnr.it
Modalità di accesso: ingresso libero