Colorectal cancer precision medicine: from patients to preclinical models, and back

Il 11/06/2018 ore 14.30 - 15.30

Sala Conferenze Cnr, Via P. Castellino 111 - 80131 Napoli

Prof. Enzo Medico from the University of Torino, will give a seminar on integrative genomics of cancer progression and resistance to treatment.

Colorectal Cancer (CRC) is a heterogeneous disease, with variable molecular pathogenesis, natural history and response to treatments. Therefore, it is important to exploit all available molecular information to enable personalized management of the disease. In this view, global transcriptional profiling of CRC samples has been exploited to challenge such heterogeneity, in three major ways: (1) Stratification of CRC in molecular subtypes, to define patient subgroups with distinct molecular and clinical features; (2) Characterization of the stromal contribution to CRC pathogenesis and response/resistance to treatments; (3) Identification of infrequent but therapeutically actionable molecular alterations. At the Candiolo Cancer Institute, large collections of preclinical models (cell lines and patient-derived xenografts) have been assembled and molecularly characterized in a decade of work. This enabled generation of therapeutic hypotheses for innovative treatments and associated predictors, followed by their prelinical testing and validation, with a perspective of rapid transfer back to patients.

Organizzato da:
Ibp-Cnr

Referente organizzativo:
Alberto Luini
Cnr - Istituto di biochimica delle proteine
Via P. Castellino, 111 - 80131 Napoli
a.luini@ibp.cnr.it
081/6132722

Modalità di accesso: ingresso libero