Different ways to recover a perturbed replication fork: implications for genome integrity and disease
Il 27/10/2017 ore 14.30 - 15.30
Sala Conferenze CNR, Via P. Castellino, 111 80131 Napoli
Pietro Pichierri, from the Department of Environment and HealthIstituto Superiore di Sanità, Rome, will give a seminar on the mechanims controlling the integrity of the human genome during DNA replication.
Accurate duplication of the genome during the S-phase of the cell cycle is inevitably harmed by a number of events that interfere with progression of the replication machinery, such as endogenously-formed DNA lesions, DNA transcription, topological constraints and DNA secondary structures. Incorrect handing of perturbed replication forks may determine formation of DNA breakage which could trigger deleterious chromosomal rearrangements such those frequently observed in human cancers. Therefore, cells evolved a sophisticated network of proteins that are responsible for keeping in shape the replication forks, allowing their safe restart whenever they stall or pause and ensuring complete duplication of the genome.
Pichierri's team seeks to understand how perturbed replication forks are recovered and whether these mechanisms may be exploited for a target therapy of human cancers.
Cnr - Istituto di biochimica delle proteine
Francesca M. Pisani
Via P. Castellino, 111 80131 Napoli
Modalità di accesso: ingresso libero