Cohesin: a ring to rule them all

Il 28/11/2014 ore 14.30 - 15.30

Sala Conferenze, CNR Via P. Castellino, 111 80131 Napoli

Dr Antonio Musio from the Istituto di Ricerca Genetica e Biomedica, CNR (Pisa), will give a seminar on cohesin that is a conserved multi-subunit protein complex comprising four core members: SMC1A, SMC3, RAD21 and STAG1/2. It ensures correct chromosome segregation, i.e. the fidelity of delivery toeach daughter cellof one copy of everychromosome. It is becoming clearer that the role of cohesin is not limited to holding sister chromatids together and ensuring correct chromosome segregation. More recent works have revealed that the universe of cohesin functions is rapidly expanding. In fact, cohesin is essential for gene expression regulation, cell cycle control, DNA damage response and genome stability maintenance. Mutations or dysregulation of cohesin and regulatory cohesin genes are associated to cohesinopathies and cancer.

Organizzato da:
Ibp-Cnr

Referente organizzativo:
Francesca M. Pisani
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
fm.pisani@ibp.cnr.it
081/6132292

Modalità di accesso: ingresso libero