Signaling at the Golgi and its role in cell migration and tumorigenesis

Il 10/07/2014 ore 14.30 - 15.30

Sala Conferenze CNR; Via P. Castellino, 111 80131 Napoli

Prof. Hess Farhan from the Biotechnology Institute Thurgau Department of Biology at the University of Konstanz (Germany) will give a seminar on  signaling to and from the secretory pathway. The two major lines of investigation are: the role of the Golgi in directional cell migration and the mutual regulation between the secretory pathway and cellular signaling cascades. The secretory pathway is composed of the rough endoplasmic reticulum (ER), the ER exit sites (ERES), the intermediate compartment (ERGIC), the Golgi apparatus and the various post Golgi compartments along the exocytic route. Organelles of the secretory pathway provide the proper environment for protein folding and post-translational modification. In addition, these cellular organelles also have other cellular functions, like the role of the Golgi apparatus in directional polarity. Upon induction of directional cell movement, the Golgi polarizes towards the leading edge. Any interference with the structural integrity of the Golgi apparatus, will result in an inhibition of directional cell migration. In Farhan's group previous work, they identified 38 kinases and phosphatases (so called Golgi-class hits) that regulated the structural integrity of the Golgi. These Golgi-class hits offer a framework for a better understanding of how directional cell movement is regulated by signal transduction. These results are likely to have a broad implication for pathological processes associated with disrupted cellular polarity, as cancer cell metastasis.

Organizzato da:
IBP, CNR

Referente organizzativo:
Alberto Luini
CNR - Istituto di biochimica delle proteine
a.luini@ibp.cnr.it
081/6132535

Modalità di accesso: ingresso libero