"Odor perception through synaptic self-organization: a full scale 3D modeling of the olfactory bulb". Seminario con Michele Migliore (Institute of Biophysics, CNR, Palermo, Italy)
Il 03/12/2013 ore 12.00 - 13.00
Istituto di Cibernetica "Eduardo Caianiello", CNR -Aula Barone - Comprensorio ex Olivetti via Campi Flegrei, 34 Pozzuoli NA
The circuits that carry out sensory processing, are usually investigated experimentally in terms of selectivity and dynamics of cell responses. These studies typically involve single cells or a small randomly selected set of cells. In the olfactory bulb, however, a clear understanding of the mechanisms involved in the odor recognition process would require the simultaneous recordings from a relevant subset of the cells activated by an odor. Thus, the functional effects of network-wide processes, such as the spatio-temporal dynamics of the mitral-granule cell network, remain relatively unknown and difficult to explore experimentally. Will be described the bottom-up approach to aid in solving this problem using the first implementation of a full scale computational model of the olfactory bulb microcircuits. Using realistic 3D cell properties and network connectivity, the model provides a new framework for investigating the functions of brain microcircuits. The model implementation, findings, and predictions will be presented and discussed in the context of the available experimental results at cellular, network and behavioural scales.
Organizzato da:
Istituto di Cibernetica 'Eduardo Caianiello' (Icib-Cnr)
Referente organizzativo:
Angela Tino
CNR - Istituto di cibernetica "Edoardo Caianiello"
via Campi Flegrei, 34 -80078- Pozzuoli Napoli
a.tino@cib.na.cnr.it
0818675253
Modalità di accesso: ingresso libero
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