Myoglobin: new comparative perspectives

Il 10/05/2013 ore 14.30 - 15.30

Aula seminari IBP, Istituto di Biochimica delle Proteine, CNR, Via P. Castellino, 111 80131 Napoli

Prof Angela Fago from the Institute of Bioscience, Aarhus University, Denmark has been focused on identifying the link between molecular properties of globin proteins (that are involved in oxygen transport) and their physiological functional roles, a topic in which our group has a leading position worldwide. Her studies have encompassed a wide range of biochemical adaptations of oxygen transport proteins in various animals, including cold-adaptation in Antarctic fish, high-altitude adaptation in deer mouse and hummingbirds, hibernation in ground squirrels and bears and diving in whales and turtles. In the past decade, she has expanded her research field to include how globin protein function is further regulated by physiological signalling molecules such as nitric oxide and nitrite that control blood flow and oxygen consumption in the heart, and have been on the forefront to elucidate these interactions in animal models. Her results on hypoxia-tolerant animals in particular have shown unprecedented adaptive molecular mechanisms that, when translated to humans, may become helpful for the therapy of stroke and heart infarct. 

Organizzato da:
CNR, Istituto di Biochimica delle Proteine

Referente organizzativo:
Cinzia Verde
IBP-CNR
Via P. Castellino, 111 Napoli
c.verde@ibp.cnr.it
081/6132710

Modalità di accesso: ingresso libero