Cytokines and microRNAs inducing cardiac protection and myocardial regeneration
Il 22/04/2013 ore 12.00 - 14.00
Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso", CNR
Aula Conferenze CNR
Via Pietro Castellino 111
80131 Napoli
Seminario del Prof. Mauro Giacca, Director, International Centre for Genetic Engineering and Biotechnology, ICGEB, Trieste
Current research interest focuses on the development of novel biotherapeutics for cardiovascular disorders, with special emphasis on the identification of growth factors and microRNAs able to induce new blood vessel formation and cardiac regeneration in patients with myocardial infarction or heart failure. He also maintains a strong interest in the molecular biology of HIV-1 infection.
Research activity is funded through grants from various public and private bodies, including the European Research Council (ERC Advanced Investigator Grants), the Italian Ministry for Education and Research, the World Antidoping Agency (WADA) Canada, the JDRF USA, the Telethon Foundation Italy, among others.
M. Giacca regularly reviews scientific manuscripts for international journals in the fields of gene therapy, cardiovascular disorders and HIV infection, and grant applications in the context of calls from the European Commission and various granting bodies throughout Europe and has published over 240 papers in peer-reviewed international journals and 20 reviews or chapters in published books and university text books. He is the author of the book "Gene Therapy", Springer ed., 2010. He regularly presents his research activity at meetings and seminars worldwide.
Selected publications
Eulalio, A., Mano, M., Dal Ferro, M., Zentilin, L., Sinagra, G., Zacchigna, S., Giacca, M. 2012. Functional screening identifies microRNAs inducing cardiac regeneration. Nature doi:10.1038/nature11739, in press
Carrer, A., Moimas, S., Zacchigna, S., Pattarini, L., Zentilin, L., Ruozi, G., Mano, M., Sinigaglia, M., Maione, F., Serini, G., Giraudo, E., Bussolino, F., Giacca, M. 2012. Neuropilin-1 identifies a subset of bone marrow Gr1_ monocytes that can induce tumor vessel normalization and inhibit tumor growth. Cancer Res DOI:10.1158/0008-5472.CAN-12-0762, in press.
Meloni, M., Descamps, B., Caporali, A., Zentilin, L., Floris, I., Giacca, M., Emanueli, C. 2012. Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice. Diabetes 61, 229-40.
Maione, F., Capano, S., Regano, D., Zentilin, L., Giacca, M., Casanovas, O., Bussolino, F., Serini, G., Giraudo, E. 2012. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest 122, 1832-48.
Macedo, A., Moriggi, M., Vasso, M., De Palma, S., Sturnega, M., Friso, G., Gelfi, C., Giacca, M., Zacchigna, S. 2012. Enhanced Athletic Performance on Multisite AAV-IGF1 Gene Transfer Coincides with Massive Modification of the Muscle Proteome. Hum Gene Ther 23, 146-57.
Lovric, J., Mano, M., Zentilin, L., Eulalio, A., Zacchigna, S., Giacca, M. 2012. Terminal Differentiation of Cardiac and Skeletal Myocytes Induces Permissivity to AAV Transduction by Relieving Inhibition Imposed by DNA Damage Response Proteins. Mol Ther 20, 2087-97.
Giacca, M., Zacchigna, S. 2012. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond. Gene Ther 19, 622-9.
Giacca, M., Zacchigna, S. 2012. Virus-mediated gene delivery for human gene therapy. J Control Release 161, 377-88.
Bortolussi, G., Zentilin, L., Baj, G., Giraudi, P., Bellarosa, C., Giacca, M., Tiribelli, C., Muro, A.F. 2012. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J 26, 1052-63.
Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., Cesselli, D., Beltrami, A.P., Giacca, M., Emanueli, C., Madeddu, P. 2011. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res 108, 1238-51.
Karvinen, H., Pasanen, E., Rissanen, T.T., Korpisalo, P., Vahakangas, E., Jazwa, A., Giacca, M., Yla-Herttuala, S. 2011. Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle. Gene Ther 18, 1166-72.
Giacca, M., Baker, A.H. 2011. Heartening results: the CUPID gene therapy trial for heart failure. Mol Ther 19, 1181-2.
Eulalio, A., Frohlich, K.S., Mano, M., Giacca, M., Vogel, J. 2011. A Candidate Approach Implicates the Secreted Salmonella Effector Protein SpvB in P-Body Disassembly. PLoS One 6, e17296.
Di Stefano, V., Giacca, M., Capogrossi, M.C., Crescenzi, M., Martelli, F. 2011. Knockdown of Cyclin-dependent Kinase Inhibitors Induces Cardiomyocyte Re-entry in the Cell Cycle. J Biol Chem 286, 8644-54.
Allouch, A., Di Primio, C., Alpi, E., Lusic, M., Arosio, D., Giacca, M., Cereseto, A. 2011. The TRIM Family Protein KAP1 Inhibits HIV-1 Integration. Cell Host Microbe 9, 484-95.
Organizzato da:
IGB-CNR
Referente organizzativo:
Sandro De Falco
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso", CNR
Aula Conferenze CNR
Via Pietro Castellino 111
80131 Napoli
sandro.defalco@igb.cnr.it
081 6132 354
Modalità di accesso: ingresso libero