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Optogenetic Control of Cholinergic Interneurons: Implication for Parkinson's Disease

Il 25/03/2013 ore 12.00

Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso"
Aula Conferenze CNR
Via Pietro Castellino 111
80131 Napoli

Seminario della Dott.ssa Marianne Amalric del CNRS UMR7291, Laboratory of Cognitive Neurosciences, Marseille Cedex, France

Research interests

The team research interest is centered on neurological diseases, experimental therapeutics and neuroplasticity, focusing on basal ganglia-related disorders (BG). Ongoing projects are centered on Parkinson’s disease (PD) and preclinical evaluation of new treatment strategies with metabotropic glutamate receptors ligands or modulators of potassium channels in animal models of PD. The involvement of the BG in sensorimotor control and cognition is assessed by a combination of behavioural, pharmacological, cellular and optogenetic approaches.

Selected Publications

  • Lopez S, Jouve L, Turle-Lorenzo N, Kerkerian-Legoff L, Salin P, Amalric M. (2012). Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity. Neurobiol Dis. 2012 6:69-77 IF: 4.01
  • Goudet C, Vilar B, Courtiol T, Deltheil T, Bessiron T, Brabet I, Oueslati N, Rigault D, Bertrand HO, McLean H, Daniel H, Amalric M, Acher F, Pin JP. (2012). A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. The FASEB J. 2012 26:1682-93. IF: 7.9.
  • Courtière A, Hardouin J, Burle B., Vidal F., Turle-Lorenzo N. Amalric M., Hasbroucq T (2011). Dynamics of executive control and motor deficits in Parkinsonian rats. J Neurosci. 31: 11929-11933. IF: IF:8.12
  • Moussa R, Poucet B, Amalric M, Sargolini F (2011) Contributions of dorsal striatal subregions to spatial alternation behaviour. Learning and memory.
    18: 444-451. IF:4.79
  • Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P, Kerkerian-LeGoff L, Acher FC, Pin JP, Amalric M. (2009) Electrophysiological and behavioral evidences that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. The FASEB J. 23:3619-3628; IF:7.12
  • Lopez S, Turle-Lorenzo N, Acher F, DeLeonibus E, Mele A, Amalric M (2007) Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson’s disease. J. Neurosci.
    27 :6701-6711. IF:8.12
  • Baunez C, Dias C, Cador M, Amalric M (2005). The subthalamic nucleus exerts an opposite control on cocaine and natural rewards. Nature Neuroscience 4 : 484-489

Organizzato da:
IGB-CNR

Referente organizzativo:
Elvira De Leonibus
CNR - Istituto di genetica e biofisica "Adriano Buzzati Traverso"
Via Pietro Castellino 111 - 80131 Napoli
elvira.deleonibus@igb.cnr.it
0816132267

Modalità di accesso: ingresso libero