PRIN 2017 - Towards a CHeap and portable InstRument for bioAnaLysis based on enAntiospecific luminescence and aBsorption essays (CHIRALAB) (DCM.AD006.162)

Area tematica

Scienze chimiche e tecnologie dei materiali

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC)

Responsabile di progetto

MARCOGIOVANNI BETTINELLI
Telefono: +390458027097
E-mail: marco.bettinelli@univr.it

Abstract

We shall take advantage of biomolecular homochirality for several separate objectives finally converging in an ambitious goal: to set up a revolutionary prototype instrument for bioanalyses based on chiroptical spectroscopies, employing only modern optoelectronic devices, i.e. avoiding expensive items for producing and detecting circularly polarized (CP) and monochromatic light (sources, polarization modulators, detectors). We constitute a multidisciplinary team with complementary expertise covering synthetic organic and inorganic chemistry, spectroscopy, characterization of molecules and materials and device fabrication and testing.

Obiettivi

The first aim of CHIRALAB is to obtain: A) new luminescent chiral molecules and materials, with high circularly polarized luminescence, CPL; B) new light absorbers with high circular dichroism, CD; C)
new bioassays, based on chiroptical switches, i.e. receptors which change their CD or CPL in response to their binding with a biologically relevant analyte. Point A) will be addressed with chiral lanthanide
complexes and organic emitters organized in chiral supramolecular structures; some Ln(III) ions feature optimal CPL in the visible (Eu, Sm, Tb); chiral orientation of -conjugated molecules can determine
large CD and CPL (UV and vis). With these latter systems, we shall address also point B). For point C) we shall use Ln(III) together with other systems with an exchangeable ligation site, where the bioanalyte
will determine the chiroptical switch, allowing for quantitative analyses. With the systems prepared in A) and B), we shall design and fabricate optoelectronic systems able to discriminate circularly polarized (CP) light: CP-OLED and CP-detectors. The ultimate goal is to set up prototype of revolutionary instrument for chiral bioanalyses (point C) based on plastic electronics.

Data inizio attività

29/10/2019

Parole chiave

Chirality, bioanalysis, luminescence

Ultimo aggiornamento: 08/06/2025