Remote control of cellular signalling triggered by magnetic switching - SIROCCO (DFM.AD003.388)
Area tematica
Scienze fisiche e tecnologie della materia
Area progettuale
Materiali innovativi (DFM.AD003)Struttura responsabile del progetto di ricerca
Istituto di Scienze Applicate e Sistemi Intelligenti "Eduardo Caianiello" (ISASI)
Responsabile di progetto
CLAUDIA TORTIGLIONE
Telefono: 0818675306
E-mail: c.tortiglione@isasi.cnr.it
Abstract
SIROCCO aims to control different pathways related with cutaneous mechanotransduction by using magnetic switchers in order to enhance wound healing. Smartly functionalized magnetic nanoparticles with oriented fragments of proteins will selectively recognize cell surface adhesion receptors (cadherins) present on the membrane of living cells. Once attached to the cellular surface, the MNPs will be activated using external magnetic fields in order to control key intracellular pathways. This ambitious goal will be validated using genetically modified 2D and 3D in vitro models and the possibility to enhance wound healing and to modulate stem cell fate will be tested.
Data inizio attività
01/05/2020
Parole chiave
magnetic nanoparticles, in vivo model, regenerative medicine
Ultimo aggiornamento: 25/04/2025