"Sensory decay and aging (sensaging)" (DSB.AD007.212)

Area tematica

Scienze biomediche

Area progettuale

Struttura responsabile del progetto di ricerca

Istituto di Biochimica e Biologia Cellulare (IBBC)

Responsabile di progetto

MARCELLO RASPA
Telefono: 0690091279
E-mail: marcello.raspa@cnr.it

Abstract

The aging process is associated with a decline in the function of our senses (Age Related Sensory Decline or ARSD). Sensory deficits may explain why elderly people report poorer quality of life and
challenges in interacting with the environment and other people. Little is known regarding genetics and environmental/lifestyle risk factors for ARSD. In this light, we will address the biology of ARSD with a
convergent methodology that integrates large population and centenarians data (environmental, lifestyle, deep phenotypes, etc.), with "omics" data and functional in vitro and in vivo studies in a very
innovative unbiased approach never applied before for the study of ARSD. Thanks to this project we plan to increase our knowledge on: a) the impact of ARSD in the daily lifestyle of the elderly, b) the role of
environmental factors (i.e. lifestyle, medications, etc.), c) the genetic risk factors and pathways and how they can predict individual ARSD, d) the interactions between ARSD genetic variants, individual
molecular phenotype and sensory deficits, and those between aging mechanism and genetic determinants. SENSAGING will not only lay the foundation for a thorough understanding of A

Data inizio attività

17/09/2019

Parole chiave

sensory systems, ageing, sensory decays

Ultimo aggiornamento: 03/05/2024