SCREENED - A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner. (DCM.AD007.057)
Area tematica
Scienze chimiche e tecnologie dei materiali
Area progettuale
Chimica e materiali per la salute e le scienze della vita (DCM.AD007)Struttura responsabile del progetto di ricerca
Istituto di Scienza, Tecnologia e Sostenibilità per lo Sviluppo dei Materiali Ceramici (ISSMC)
Responsabile di progetto
MONICA SANDRI
Telefono: 0546/699761
E-mail: monica.sandri@istec.cnr.it
Abstract
SCREENED will develop 3 different three-dimensional in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach.
These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions.
Obiettivi
ISTEC is involved to develop new superparamagnetic biocompatible and biomimetic particles that will be used to produce "magnetic cells" to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs.
Data inizio attività
01/12/2018
Parole chiave
Bioceramic, magnetic nanoparticles, magnetic cells
Ultimo aggiornamento: 20/01/2025