Cardiac Troponins and Heart Failure (carTn-HF) (DSB.AD006.239)
Area tematica
Area progettuale
Biologia Molecolare/Cellulare (DSB.AD006)Struttura responsabile del progetto di ricerca
Istituto di fisiologia clinica (IFC)
Responsabile di progetto
CHIARA CASELLI
Telefono: 050 3153229
E-mail: chiara.caselli@ifc.cnr.it
Abstract
This study could provide insights into the molecular changes that occur in cardiac tissue in both HF pediatric and adult patients. It is unclear if these mechanisms are the cause or the effect of the failing heart, but they could represent a possible future therapeutic targets (Movassagh M, et al 2011; Sabia C, et al 2017). In particular, the deregulation in the expression of specific miRNAs associated to myocardial dysfunction led to develop research for the application of antagomir-based therapy in the patients with HF (van Rooij E and Kauppinen S 2014). Thus, results from this study could allow to assess whether these molecules can be useful for diagnosis and prognosis in the current clinical setting for patients with HF, also addressing for a personalized management and a targeted therapy.
Obiettivi
This study could provide insights into the molecular changes that occur in cardiac tissue in both HF pediatric and adult patients. It is unclear if these mechanisms are the cause or the effect of the failing heart, but they could represent a possible future therapeutic targets (Movassagh M, et al 2011; Sabia C, et al 2017). In particular, the deregulation in the expression of specific miRNAs associated to myocardial dysfunction led to develop research for the application of antagomir-based therapy in the patients with HF (van Rooij E and Kauppinen S 2014). Thus, results from this study could allow to assess whether these molecules can be useful for diagnosis and prognosis in the current clinical setting for patients with HF, also addressing for a personalized management and a targeted therapy.
Data inizio attività
01/01/2019
Parole chiave
heart failure
Ultimo aggiornamento: 25/06/2025