Istituto di Biomembrane, Bioenergetica e Biotecnologie Molecolari (IBIOM)

Direttore

Prof CESARE INDIVERI

E-mail: c.indiveri@ibiom.cnr.it
Telefono: 080-5929818

Profilo

RESEARCH INTEREST:
o Nutrition and metabolism in health and diseases.
o Absorption and Distribution of Nutrients.
o Drug Design
o Absorption, Distribution and Excretions of Drugs.

PROTEIN EXPRESSION AND PURIFICATION:
o Large-scale production of mammalian and plant recombinant membrane transporters and enzymes using bacteria (E. coli), yeast (P. pastoris) and human cell lines (HEK293 free style).
o Protein purification by affinity chromatography and SEC on FPLC systems.
o Polyclonal antibody production from entire proteins and peptides.

MEMBRANE TRANSPORTER CHARACTERIZATION:
o Transport measurements by radioisotope and fluorescence techniques.
o Transport assays in intact cells and in isolated organelles.
o Transport assays in artificial membrane system (proteoliposomes).
o Membrane transport mechanisms and structure/function relationships (homology modeling, site directed mutagenesis and chemical labeling).

MEMBRANE TRANSPORTER AS NOVEL TARGETS IN DRUG DISCOVERY
o Effects of endogenous and exogenous compounds on function of membrane transporters.
o Platforms for drug-transporter interaction studies.
o Computational biology: protein structure prediction; interactions with chemicals and drugs.
o Drug discovery and design with lead compounds identification.
o Drug and pro-drug absorption, disposition and side effects.

PUBLICATIONS: http://www.ncbi.nlm.nih.gov/pubmed?term=Indiveri%20C%5BAuthor%5D

PATENT: EP 2247621 B: https://www.google.com/patents/EP2247621B1?cl=un

WEBSITES:
https://loop.frontiersin.org/people/313872/overview
https://www.unical.it/portale/strutture/dipartimenti_240/dibest/docenti/indiveri/
https://it.linkedin.com/in/cesare-indiveri-8aa95236
https://www.researchgate.net/profile/Cesare_Indiveri