Seminario "UNC93B1, the endosomal TLR chaperone, controls the activation of IRE1? and STING in dendritic cells"
Il 23/06/2023 ore 12.00 - 13.00
Seminar room via Pietro Castellino, 111 Napoli Area di Ricerca Na 1
UNC93B1, a highly conserved 12-membrane spanning molecule residing in the endoplasmic reticulum (ER), has been identified as a key regulator in the trafficking and folding to endosomes of intracellular Toll-like
receptors (TLRs) that detect microbial nucleic acids. We have shown that UNC93B1, also binds the Ca2+sensor stromal interaction molecule 1 or STIM1 in the ER and that this association is essential for antigen
cross presentation.
Our unpublished data now suggest that in addition to endosomal TLRs and STIM1, UNC3B1 also controls the activation of Inositol requiring enzyme 1- alpha (IRE1a), the major ER stress
sensor, and stimulator of interferon genes (STING), the type I interferon cytosolic DNA sensor in dendritic cells.
Speaker is dr. Benedicte Manoury (Institut Necker Enfants Malades, Paris).
Organizzato da:
IBBC
Referente organizzativo:
Piergiuseppe De Berardinis
Istituto di biochimica e biologia cellulare
Via Pietro Castellino n.111 Napoli (NA)
piergiuseppe.deberardinis@cnr.it
Modalità di accesso: ingresso libero
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