7th Arturo Falaschi Lecture
Il 22/05/2017 ore 11.30 - 13.30
Nuovo polo didattico, Aula 1 - Polo Universitario Cravino - Via Ferrata 9 - Pavia
Il giorno 22 Maggio 2017 si terrà la settima Arturo Falaschi Lecture.
Quest'anno la conferenza dal titolo 'Nusinersen (SPINRAZA): the first FDA-approved treatment for SMA' sarà tenuta dal Professor Adrian Krainer (Cold Spring Harbor Laboratory - Cold Spring Harbor – NY - USA). La conferenza si svolgerà presso il Nuovo polo didattico, Aula 1, Polo Universitario Cravino di Pavia.
Adrian Krainer’s lab studies the mechanisms of RNA splicing, ways in which they go awry in disease, and the means by which faulty splicing can be corrected. In particular, they study splicing in spinal muscular atrophy (SMA), a neuromuscular disease that is the leading genetic cause of death in infants. In SMA, a gene called SMN2 is spliced incorrectly, making it only partially functional. The Krainer lab is able to correct this defect using a powerful therapeutic approach. It is possible to stimulate protein production by altering mRNA splicing through the introduction of chemically modified pieces of RNA called antisense oligonucleotides (ASOs) into the spinal cords of mice. Previously, using ASOs in mice carrying a transgene of human SMN2, they developed a model for SMA using a technique they called TSUNAMI (shorthand for targeting splicing using negative ASOs to model illness). Recently, this method has been approved by the U.S. Food and Drug Administration to treat children and adults with spinal muscular atrophy (SMA). The Krainer lab has also worked to shed light on the role of splicing proteins in cancer. They have found that the splicing factor SRSF1 functions as an oncogene stimulating the proliferation of immortal cells. They found that SRSF1 can actually stop cell growth by stabilizing a powerful tumor suppressor protein, called p53—suggesting that the cell is responding to the aberrant SRSF1 activity. This discovery offers insight into how tumors arise and the pathways that lead to transformation.
Fondazione Adriano Buzzati-Traverso, Società Italiana di Biofisica e Biologia Molecolare (SIBBM), Dottorato in Genetica, Biologia Molecolarre e Cellulare, Università di Pavia
Via Abbiategrasso 207 - 27100 PAVIA
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