The nuclear envelope and LINCs to human disease
Il 06/10/2015 ore 12.00 - 13.00
Sala Conferenze CNR, Via P. Castellino 111 80131 Napoli
Prof Brian Burke from the Institute of Medical Biology, in Singapore, will give a seminar on the nuclear envelop and human diseases.The nuclear envelope (NE) forms the interface between the nucleus and cytoplasm, and as such determines the biochemical identities of both compartments. While it is well established that the NE plays an essential role in defining global nuclear architecture, it has only recently become apparent that it has a similar role in cytoplasmic organization. This notion is reflected in the fact that nuclear structures are mechanically coupled to elements of the cytoskeleton. This coupling is mediated to a large extent by LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) composed of KASH-domain proteins of the outer nuclear membrane (ONM) and SUN domain proteins of the inner nuclear membrane (INM). LINC complexes are now known to have roles in a number of processes, including nuclear migration and anchoring in multiple cell types. This has been highlighted by findings that several human diseases, such as muscular dystrophy and cerebellar ataxia, are associated with defects in LINC complex components. In this talk I will describe how different LINC complex isofoms can play essential roles in both nuclear positioning and anchoring as well as in global nuclear organization and remodeling during differentiation. Prof Burke will provide examples of how LINC complex dysfunction in humans can result in phenotypes as diverse as hearing loss and infertility.
Organizzato da:
IBP, Cnr
Referente organizzativo:
Alberto Luini
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
a.luini@ibp.cnr.it
081/6132535
Modalità di accesso: ingresso libero
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