Using Systems Biology approach to evaluate human immunology of adjuvanted vaccines

Il 27/03/2015 ore 14.30 - 15.30

Sala Conferenze, Area della Ricerca Na1, Via P. Castellino, 111 80131 Napoli

Prof. DJ Lewis will give an overview on human vaccine development that remains challenging because of the highly sophisticated evasion mechanisms of pathogens for which vaccines are not yet available. Recent years have witnessed both successes and failures of novel vaccine design and the strength of iterative approaches is increasingly appreciated. These combine discovery of novel antigens, adjuvants and vectors in the preclinical stage with computational analyses of clinical data to accelerate vaccine design. Reverse and structural vaccinology have revealed novel antigen candidates and molecular immunology has led to the formulation of promising adjuvants. Gene expression profiles and immune parameters in patients, vaccinees and healthy controls have formed the basis for biosignatures that will provide guidelines for future vaccine design.

Prof. Lewis is currently Head of Clinical Operations, Consultant Physician at NIHR Clinical Research Facility, Hammersmith Hospital, Imperial College NHS Trust, London, UK

Organizzato da:
Ibp-Cnr

Referente organizzativo:
Diana Boraschi
CNR - Istituto di biochimica delle proteine
d.boraschi@ibp.cnr.it

Modalità di accesso: ingresso libero