Cell and molecular processes induced by magnetic hyperthermia in vitro and in vivo
Il 17/12/2014 ore 11.00 - 13.00
Imem-Cnr, Parco Area delle Scienze 37/a, 43124 Parma, Italy
Sala A
Dott.ssa Claudia Tortiglione
Istituto di Cibernetica "E. Caianiello" - CNR
Ricercatore ospite: Franca Albertini
The remarkable amenability of aquatic invertebrates to laboratory manipulation has already made a few species belonging to the phylum Cnidaria as attracting systems for exploring animal development. The proliferation of molecular and genomic tools, including the whole genomic sequence of the freshwater polyp Hydra vulgaris and the starlet sea anemone Nematostella vectensis, further enhances the promise of these species to investigate the evolution of key aspects of developmental biology. Over the past years, our group adopted these models as amenable systems to be approached by nanoparticles, showing the great advantages offered by the novel nanomaterials to address biological issues.
An overview of different issues faced in Hydra by using nanoparticles will be presented, from tissue plasticity, to stem cell differentiation, up to the molecular mechanisms induced by hyperthermia. In particular, the possibility to study cell function in vivo by mean of nanoparticle mediated cell ablation will be shown, focusing on light and magnetic field as physical stimuli triggering heat generation4. While for biologists the new smart nanodevices represent advanced bioprobes merging multiple properties in single objects, from the chemistry point of view we recommend Hydra as novel, fast time, cost effective in vivo model for high-throughput evaluation of nanomaterials impact on environment and for translational medicine.
Organizzato da:
Imem-Cnr
Referente organizzativo:
Franca Albertini
CNR - Istituto dei materiali per l'elettronica ed il magnetismo
Imem-Cnr, Parco Area delle Scienze 37/a, 43124 Parma, Italy
franca.albertini@imem.cnr.it
Modalità di accesso: ingresso libero
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