Ctf4 homotrimer for helicase-polymerase coupling in the eukaryotic replisome

Il 25/07/2014 ore 14.30 - 15.30

Sala Conferenze CNR, Via P. Castellino, 111 80131 Napoli

Dr Alessandro Costa's  research (CRUK London Research Institute) aims to understand how macromolecular machines involved in DNA replication and recombination function to preserve chromosome integrity. A hallmark of cancer cells is genomic instability, arising from errors in the mechanisms that maintain gene copy number and chromosome ploidy.  To address these issues, Dr Costa's group employs a combination of single particle electron microscopy and biochemistry, to generate mechanistic models that explain the basis of DNA replication and chromosome stability maintenance. By describing the architecture and dynamics of the DNA replication/recombination machinery, they seek to establish a molecular framework that explains how higher eukaryotes respond to DNA damage and how cell proliferation is regulated to avoid tumorigenesis.

Organizzato da:
IBP, CNR

Referente organizzativo:
Francesca Maria Pisani
CNR - Istituto di biochimica delle proteine
Via P. Castellino, 111 80131 Napoli
fm.pisani@ibp.cnr.it
081/6132292

Modalità di accesso: ingresso libero